Professor Franz Matschinsky is one of the founders of the field of the World Islet Research. He is also a postdoctoral mentor of the company’s founder, Dr. Changhong Li. In recognition of Professor Matchnsky’s outstanding contribution to Islet Research and thank him for his guidance on islet research, we are honored to name our islet research center “Matschinsky Islet Research Center”. We hope that through our efforts, we can carry forward professor Matschinsky’s islet research work and further develop it.
Personal Profile of Professor Matschinsky at the University of Pennsylvania:
Professor Matschinsky received the Banting award, the Noble Prize in the field of diabetes in 1995:
Assessment of Islet function plays a crucial role in basic research on hypoglycemia and diabetes, translational medicine research, and research on new drugs.
An important aspect of assessing islet function status (including insulin secretion and pancreatic glucagon secretion) is the measurement of hormone secretion of the islet under various stimulating conditions, and the main experimental technical platform including islet separation, purification, and culture from various mouse models, followed by islets perifusion. This includes the assessment of various stimulating insulin secretions, such as ramp perifusion.
If the Glucose-Stimulated Insulin Secretion (GSIS) can be evaluated by glucose ramp to determine the GSIS threshold value and the maximum stimulation concentration, it also can finish the insulin secretion experiments under the leucine stimulation and ∂-ketoisocaproate acid (KIC) stimulation, and evaluate the effect of a particular drug or compound on insulin secretion, the effect on GSIS and so on.
In addition, batch incubation of the islets can achieve a “high throughput” assessment of islet function, especially suitable for the preliminary screen of islet function, drug screening and etc., but also to achieve the evaluation of the islet ß-cell secretion and ∂-cell pancreatic glucagon secretion simultaneously. Hormone Measurements adopt the HTRF insulin assay, and it can achieve low-cost hormone measurement in large samples.